The Evidence Library

Acetylated carnitine; supports mitochondrial fatty-acid transport/energy production and provides acetyl groups for acetylcholine; targets physical and mental fatigue and cognitive vitality.

Soothing botanical supporting digestive comfort and a healthy gut/inflammatory response; small supportive role in the RENEW recovery stack.

Universal (both water- and fat-soluble) antioxidant and mitochondrial cofactor; regenerates other antioxidants (vitamin C, E, glutathione) and supports cellular energy metabolism — an "antioxidant network" anchor.

A stable plant vitamin-C source that also promotes procollagen production and inhibits the collagen-degrading enzyme MMP-1 while fighting glycation — feeding collagen synthesis and slowing its breakdown.

Adaptogen that supports the body's stress response, lowers stress-driven cortisol, and supports sleep quality and recovery in the PM stack.

Potent xanthophyll carotenoid antioxidant; quenches oxidative stress, supports skin and eye health, and protects mitochondrial/cell membranes. Antioxidant backbone of the renew stack.

Immune & adaptogenic Qi tonic (TCM); supports cellular resilience and healthy immune aging (immunosenescence). Telomerase claims are reserved for concentrated cycloastragenol/TA-65, not this extract.

Non-hormonal cognitive support in the women’s formula — memory, attention, and processing for the “brain fog” of the menopausal transition. Cholinergic and antioxidant mechanisms; benefit builds with sustained daily use.

Plant-source silicon to support the body's own collagen synthesis (silicon is a cofactor for prolyl hydroxylase) and connective-tissue, hair, skin, and nail integrity; rounds out the structural RENEW stack with collagen + HA.

AMPK-activating alkaloid; supports healthy glucose and lipid metabolism. The metabolic anchor — used as a standalone because of its potency and interaction profile.

Trace-mineral hormone modulator — supports a healthy free-testosterone-to-estradiol balance and lowers SHBG in men; supports calcium/vitamin D and steroid-hormone metabolism in women. A low-dose "restore not replace" enabler, not a hormone source.

5-LOX-inhibiting resin extract that supports a healthy inflammatory response and joint comfort/mobility.

Consolidated to a once-daily dose, split AM + PM (Cognizin); choline donor for membranes and cognition, and supports youthful cholinergic→GH signaling (a signaling role, not a magnitude claim).

Traditional "desert ginseng" tonic for vitality, stamina, and healthy aging; echinacoside/verbascoside (acteoside) phenylethanoid glycosides drive neurotrophic, anti-fatigue, and steroidogenic-support signaling. Restorative "kidney-yang" tonic in the brand's "restore, not replace" framing.

**Functional carrier/excipient** — a spray-dried MCT (medium-chain triglyceride) powder that acts as a lipid matrix to improve dispersibility and co-absorption of fat-soluble actives, plus a clean, rapidly metabolized energy substrate. Not a "hero" actor; included for formulation function.

Essential trace mineral and cofactor for cytochrome c oxidase (energy), superoxide dismutase (antioxidant defense), lysyl oxidase (collagen/elastin cross-linking), and ceruloplasmin. **Included specifically to balance chronic zinc supplementation** elsewhere in the formula.

Mitochondrial electron-transport cofactor and lipid-phase antioxidant; supports cellular energy (ATP) production and cardiovascular function. Replenishes a coenzyme that declines with age and with statin use.

The best-evidenced compound for the muscle reserve of aging — creatine plus resistance training increases lean mass and strength in older adults, with emerging bone and cognitive benefits. A companion stick (too bulky for the sachet).

Hero anti-inflammatory polyphenol; supports a healthy inflammatory response, joint comfort, and antioxidant defense.

Short-term, cyclical support of the LH–testosterone axis via the pituitary/testes; positioned as a seasonal "nudge," NOT a continuous testosterone driver.

Low/physiologic adrenal-androgen precursor to support libido, vitality, and well-being in midlife/postmenopausal women whose endogenous DHEA has declined.

Supports healthy estrogen metabolism (favoring the protective 2-hydroxyestrone pathway) and aromatase balance.

Traditional vitality/libido and circulatory-support botanical; icariin acts on the nitric-oxide / cGMP / PDE5 pathway and on bone metabolism.

TCM kidney/liver tonic studied for blood-pressure support, connective-tissue/bone, and antioxidant activity; contributes structural-restorative tone to the RENEW stack. Source of pinoresinol diglucoside (PDG), aucubin, geniposidic acid, and chlorogenic acid.

Flavonoid senolytic / senotherapeutic — at the higher cyclic dose, helps clear senescent ("zombie") cells; at the daily dose, antioxidant and anti-inflammatory support. Anchors the "renew" / cellular-cleanup story.

The women’s-formula bone actor — an ER-beta-preferential isoflavone that supports bone mineral density and healthy bone turnover through the post-menopausal bone-loss window. Phytoestrogen: Complete-only, with an estrogen-sensitive advisory.

At a classical stomach-harmonizing dose, the envoy (Sheng Jiang) that buffers the stack; also anti-inflammatory and digestion-supporting.

Raised to a clinically meaningful dose for double duty: an inhibitory neurotransmitter that deepens sleep and lowers night cortisol, and the primary amino acid the body builds its own collagen from.

TCM Liver/Kidney yin & blood tonic as a standardized extract — the yin anchor balancing the yang-forward morning stack; zeaxanthin/eye support is a secondary bonus (food-dose whole berries recommended in the diet guide).

The plant world's closest thing to a "collagen builder" — its triterpenes (asiaticoside, madecassoside) stimulate type I & III collagen synthesis; long used for skin firmness, wound healing, and vein integrity.

The base's own daily AMPK activator at the clinically studied Actiponin dose — a caloric-restriction mimic (the stronger AMPK lever, berberine, is a separate SKU).

Supports skin moisture retention and dermal matrix hydration; complements the endogenous collagen-building system + silica in the structural RENEW stack. Restores the skin's own water-binding matrix rather than topically masking.

Direct substrate for endothelial nitric-oxide synthase (eNOS) → nitric oxide → vasodilation. Supports the body's own NO production for blood-flow, endothelial, and exercise-performance support.

Recycled to L-arginine in the kidney (bypassing arginine's high intestinal first-pass metabolism), raising plasma arginine and NO more efficiently than oral arginine itself → vasodilation and blood flow.

Bioactive, pre-methylated folate; supports homocysteine remethylation and one-carbon/methylation metabolism independent of MTHFR genotype.

A direct amino-acid precursor of collagen (with glycine); the substrate that vitamin C-dependent hydroxylases convert to hydroxyproline to stabilize the collagen triple helix.

Calming amino acid (from tea) that promotes relaxation without sedation and supports sleep quality; pairs with GABA/glycine in the PM stack.

Non-hormonal calm and sleep support in the women’s formula — eases occasional anxiousness and supports sleep quality via raised endogenous GABA tone. An aroma-retentive form also lends a gentle lemon top-note to the sachet.

Non-hormonal adaptogen for libido, mood, energy, and menopausal comfort; supports the body's own hormonal signaling rather than supplying hormones.

Switched to the bisglycinate form delivering markedly more elemental magnesium than the old citrate; cofactor for 300+ enzymes, tunes the GABA-A receptor, supports sleep, and the glycine bond is a bonus.

An essential trace cofactor for prolidase (which recycles proline) and the glycosyl-transferases that assemble collagen; supplied in the chelated form for absorption and GI comfort.

Bioactive B12; cofactor with folate in homocysteine remethylation and methylation; supports nerve and red-blood-cell function and energy metabolism.

Dopaminergic support for mood, motivation, and stress resilience; indirect support of the LH–testosterone axis (via dopamine-driven prolactin suppression) in men; male reproductive/semen-quality support.

Insulin-sensitizing carbocyclic sugar and second messenger in FSH/insulin signaling; supports healthy insulin sensitivity, menstrual-cycle regularity, and female hormonal balance. Female-specific metabolic/hormonal support actor.

Cysteine donor; rate-limiting substrate for glutathione synthesis; supports the body's own antioxidant/redox defense — squarely on the "restore endogenous capacity" brand thesis.

Standardized root extract, dosed to work: binds SHBG to free the testosterone you already make (endogenous, no exogenous push), with prostate/BPH support and mild 5-α-reductase (hair) activity.

NAD⁺ salvage-pathway precursor supporting sirtuin activity and DNA repair; the non-flushing form of B3.

Direct NAD⁺ precursor at a clinically studied daily dose (RISE); restores the NAD⁺ that fuels sirtuin-driven DNA repair and mitochondrial function, which declines with age. Cleared as a lawful US dietary ingredient (2025).

The highest-leverage anti-inflammatory and among the best human data for cardiovascular and cognitive protection; in the DO-HEALTH trial, omega-3 slowed DNA-methylation clocks of biological aging. A companion softgel (fish or algal/vegan).

Adaptogen supporting healthy energy, stress resilience, and healthy sexual function.

A low-FODMAP soluble fiber for gentle daily regularity — it normalizes stool in both directions, is tasteless and non-gelling, and buffers the stack without the gas that fermentable fibers like inulin can cause.

Membrane phospholipid that supports cognition and helps blunt the stress-driven cortisol response — bridges the PM stress-down-regulation and recovery goals of RENEW.

Non-hormonal skin support in the women’s formula — replenishes the stratum-corneum ceramides that decline with age and estrogen loss, supporting skin hydration, elasticity, and barrier function. Complements the endogenous-collagen system.

Procyanidin/flavonoid-rich French maritime pine bark extract; antioxidant and endothelial support — increases eNOS activity / nitric-oxide availability and reduces oxidative stress and platelet aggregation.

Flavonoid antioxidant / anti-inflammatory; classic senolytic co-factor (pairs with fisetin/dasatinib in research); supports vascular tone and a healthy inflammatory response.

Foundational TCM kidney-Yin tonic; source of catalpol and iridoid glycosides studied (preclinically) for anti-inflammatory, anti-oxidant, bone-metabolism, and renal-protective activity. A "restorative/renew" base herb in the RENEW stack.

Iconic longevity mushroom, now dosed to a working standardized extract (β-glucans/triterpenes); immune modulation (Cochrane signal) and Shen-calming sleep support (mild antiplatelet note).

SIRT1 activator, now co-timed in the morning with NMN + TMG so the activator fires alongside its NAD⁺ substrate; supports sirtuin/epigenetic maintenance.

Adaptogen; supports stress resilience, reduces stress-related fatigue, and supports mental performance under fatigue. On-brand: modulates the body's own stress response rather than stimulating.

Non-hormonal mood-and-spirit support across the menopausal transition in the women’s formula — eases occasional low mood and anxiousness and supports restful sleep. Serotonergic/monoaminergic mechanism; supports the body’s own mood regulation.

Five-flavor adaptogen standardized to its lignans; secures Jing / calms Shen (TCM) and provides lignan hepatoprotection (Western). Note: CYP3A4 interaction — see the safety brief.

Ayurvedic women's reproductive/hormonal tonic; supports hormonal balance, stress resilience, and well-being across the menopausal transition.

Polyamine that induces autophagy ("cellular self-cleaning"); supports cognitive and cardiovascular healthy aging. Complements the renew/cellular-renewal narrative.

**Natural, zero-calorie sweetener / palatability agent** — masks bitterness of herbal actives and improves sachet taste without sugar or glycemic load. Functional excipient, not a health actor.

The premier TCM sleep botanical — nourishes Heart & Liver blood to calm the spirit (Shen) for restorative sleep; modern anxiolytic and sleep-quality evidence anchors the endogenous-calm system.

The most potent dietary NRF2 activator — it switches on the body's own antioxidant and detox genes (glutathione, phase-II enzymes) rather than adding a finite antioxidant. Delivered as glucoraphanin with active myrosinase for in-vivo conversion (hormesis).

Non-hormonal comfort support for the menopausal transition in the women’s formula — hot flushes, irritability, and sleep. A purified, non-estrogenic cytoplasmic pollen extract; the one new vasomotor lever safe enough for the estrogen-sensitive Foundation build.

Methyl donor — supplies methyl groups to offset the methylation demand created by NAD+ precursor metabolism (NMN/niacinamide), and supports healthy homocysteine metabolism. Methylation-support partner to NMN.

Restore the body's own testosterone output endogenously and blunt cortisol — the brand's flagship "restore, not replace" androgen support, paired with energy, libido, and stress-resilience benefits.

Pyrimidine nucleotide; substrate for membrane phospholipid (CDP-choline pathway) synthesis. Pairs with CDP-choline and DHA to support synaptic membrane formation.

Essential precursor of Coenzyme A (CoA) and acyl-carrier protein — central to fatty-acid synthesis/oxidation, the TCA cycle, and adrenal/steroid and energy metabolism. Supports the body's own energy-production machinery.

Cofactor (as pyridoxal-5'-phosphate, P5P) for >100 enzymes — amino-acid metabolism, neurotransmitter synthesis (serotonin, GABA, dopamine), and homocysteine clearance. Supports the body's own neurotransmitter and methylation machinery.

Water-soluble antioxidant and essential cofactor for collagen synthesis, immune function, and catecholamine metabolism; regenerates other antioxidants and supports endothelial nitric-oxide bioavailability.

Foundational fat-soluble prohormone supporting calcium homeostasis, bone integrity, normal immune function, and muscle function — restores a commonly low endogenous status rather than overriding it.

Primary lipid-phase (fat-soluble) antioxidant; protects cell membranes and LDL particles from lipid peroxidation. Mixed tocopherols (incl. gamma) chosen deliberately over high-dose alpha alone.

Activates vitamin-K-dependent proteins (osteocalcin, matrix Gla protein) that direct calcium INTO bone and AWAY from arteries — the rational partner to D3. Supports the body's own calcium-routing machinery.

Essential cofactor for the body's own testosterone synthesis (Leydig-cell steroidogenesis) plus immune and antioxidant support — a true "restore, not replace" nutrient: it permits endogenous hormone production rather than supplying any hormone.