The Evidence Library

Acetylated carnitine; supports mitochondrial fatty-acid transport/energy production and provides acetyl groups for acetylcholine; targets physical and mental fatigue and cognitive vitality.

Soothing botanical supporting digestive comfort and a healthy gut/inflammatory response; small supportive role in the RENEW recovery stack.

Universal (both water- and fat-soluble) antioxidant and mitochondrial cofactor; regenerates other antioxidants (vitamin C, E, glutathione) and supports cellular energy metabolism — an "antioxidant network" anchor.

Adaptogen (triterpene saponins / aralosides-elatosides) used to support stress resilience, physical working capacity, and energy in the RISE stack. Supports the body's own stress-adaptation response.

Adaptogen that supports the body's stress response, lowers stress-driven cortisol, and supports sleep quality and recovery in the PM stack.

Potent xanthophyll carotenoid antioxidant; quenches oxidative stress, supports skin and eye health, and protects mitochondrial/cell membranes. Antioxidant backbone of the renew stack.

TCM longevity/Qi tonic; source of cycloastragenol/astragalosides studied for telomerase support and immune-aging (immunosenescence) modulation — the "longevity" pillar of RISE. Supports the body's own cellular maintenance and immune resilience.

Plant-source silicon to support the body's own collagen synthesis (silicon is a cofactor for prolyl hydroxylase) and connective-tissue, hair, skin, and nail integrity; rounds out the structural RENEW stack with collagen + HA.

AMPK-activating alkaloid; supports healthy glucose and lipid metabolism. The metabolic anchor — used as a standalone because of its potency and interaction profile.

Trace-mineral hormone modulator — supports a healthy free-testosterone-to-estradiol balance and lowers SHBG in men; supports calcium/vitamin D and steroid-hormone metabolism in women. A low-dose "restore not replace" enabler, not a hormone source.

5-LOX-inhibiting resin extract that supports a healthy inflammatory response and joint comfort/mobility.

Choline donor and phospholipid precursor; supports acetylcholine synthesis and neuronal membrane integrity for memory, focus, and attention.

Traditional "desert ginseng" tonic for vitality, stamina, and healthy aging; echinacoside/verbascoside (acteoside) phenylethanoid glycosides drive neurotrophic, anti-fatigue, and steroidogenic-support signaling. Restorative "kidney-yang" tonic in the brand's "restore, not replace" framing.

**Functional carrier/excipient** — a spray-dried MCT (medium-chain triglyceride) powder that acts as a lipid matrix to improve dispersibility and co-absorption of fat-soluble actives, plus a clean, rapidly metabolized energy substrate. Not a "hero" actor; included for formulation function.

Forskolin directly activates adenylate cyclase → raises intracellular cAMP → supports lipolysis, lean-mass/body-composition signaling, and (in men) free-testosterone support. A metabolic/"vigor" lever that works downstream of hormone receptors rather than supplying hormones.

Supplies di-/tripeptide signaling fragments (proline-hydroxyproline) that the body uses to support its own dermal and connective-tissue collagen synthesis — on-brand "restore the body's own output" rather than topical/injected replacement.

Essential trace mineral and cofactor for cytochrome c oxidase (energy), superoxide dismutase (antioxidant defense), lysyl oxidase (collagen/elastin cross-linking), and ceruloplasmin. **Included specifically to balance chronic zinc supplementation** elsewhere in the formula.

Mitochondrial electron-transport cofactor and lipid-phase antioxidant; supports cellular energy (ATP) production and cardiovascular function. Replenishes a coenzyme that declines with age and with statin use.

TCM Yang/kidney-lung tonic studied for aerobic capacity, oxygen utilization, and anti-fatigue/cellular energy support; contributes to recovery/restoration in the RENEW stack. Supports the body's own energy metabolism rather than acting as a stimulant.

Hero anti-inflammatory polyphenol; supports a healthy inflammatory response, joint comfort, and antioxidant defense.

Short-term, cyclical support of the LH–testosterone axis via the pituitary/testes; positioned as a seasonal "nudge," NOT a continuous testosterone driver.

Low/physiologic adrenal-androgen precursor to support libido, vitality, and well-being in midlife/postmenopausal women whose endogenous DHEA has declined.

Supports healthy estrogen metabolism (favoring the protective 2-hydroxyestrone pathway) and aromatase balance.

Traditional vitality/libido and circulatory-support botanical; icariin acts on the nitric-oxide / cGMP / PDE5 pathway and on bone metabolism.

TCM kidney/liver tonic studied for blood-pressure support, connective-tissue/bone, and antioxidant activity; contributes structural-restorative tone to the RENEW stack. Source of pinoresinol diglucoside (PDG), aucubin, geniposidic acid, and chlorogenic acid.

Flavonoid senolytic / senotherapeutic — at the higher cyclic dose, helps clear senescent ("zombie") cells; at the daily dose, antioxidant and anti-inflammatory support. Anchors the "renew" / cellular-cleanup story.

Primary inhibitory neurotransmitter; supports relaxation and a calm transition to sleep in the evening RENEW stack.

Standardized ginger extract supporting a healthy inflammatory response and joint comfort; complements Boswellia and curcumin in the RENEW anti-inflammatory triad.

Inhibitory amino acid that lowers core body temperature and supports sleep onset and quality; complements the PM relaxation stack.

Antioxidant and general-wellbeing support; carotenoid (zeaxanthin) source supporting eye health; supports healthy energy and subjective wellbeing.

Adaptogenic herb and **AMPK activator** (gypenoside/damulin saponins) — supports the body's own metabolic regulation, energy, and healthy body composition. In-stack AMPK complement (the gentle, non-interacting counterpart to standalone berberine).

Supports skin moisture retention and dermal matrix hydration; complements collagen peptides + silica in the structural RENEW stack. Restores the skin's own water-binding matrix rather than topically masking.

**Prebiotic fiber + functional excipient** — selectively feeds beneficial gut bacteria (bifidobacteria) and serves as a clean-label bulking/flow agent and mild sweetness/mouthfeel aid in the sachet. Supports the body's own microbiome.

Direct substrate for endothelial nitric-oxide synthase (eNOS) → nitric oxide → vasodilation. Supports the body's own NO production for blood-flow, endothelial, and exercise-performance support.

Recycled to L-arginine in the kidney (bypassing arginine's high intestinal first-pass metabolism), raising plasma arginine and NO more efficiently than oral arginine itself → vasodilation and blood flow.

Bioactive, pre-methylated folate; supports homocysteine remethylation and one-carbon/methylation metabolism independent of MTHFR genotype.

Calming amino acid (from tea) that promotes relaxation without sedation and supports sleep quality; pairs with GABA/glycine in the PM stack.

Low-molecular-weight (oligomerized) proanthocyanidin polyphenol; antioxidant supporting peripheral circulation, exercise recovery, and reduction of abdominal/visceral fat.

Non-hormonal adaptogen for libido, mood, energy, and menopausal comfort; supports the body's own hormonal signaling rather than supplying hormones.

Essential mineral cofactor for >300 enzymes; supports nervous-system relaxation, muscle function, and normal sleep. Many adults 35–65 run low.

Bioactive B12; cofactor with folate in homocysteine remethylation and methylation; supports nerve and red-blood-cell function and energy metabolism.

Dopaminergic support for mood, motivation, and stress resilience; indirect support of the LH–testosterone axis (via dopamine-driven prolactin suppression) in men; male reproductive/semen-quality support.

Insulin-sensitizing carbocyclic sugar and second messenger in FSH/insulin signaling; supports healthy insulin sensitivity, menstrual-cycle regularity, and female hormonal balance. Female-specific metabolic/hormonal support actor.

Cysteine donor; rate-limiting substrate for glutathione synthesis; supports the body's own antioxidant/redox defense — squarely on the "restore endogenous capacity" brand thesis.

Binds SHBG (lignans free testosterone) and supports normal urinary flow / prostate comfort — a "restore, not replace" lever that helps the body's existing testosterone stay bioavailable rather than supplying exogenous hormone.

NAD+ precursor and the most direct NAD+ building block; supports DNA-repair enzymes (PARPs/sirtuins use NAD+), skin barrier, and cellular energy. Flush-free B3 — complements NMN in the NAD+ pathway.

NAD+ precursor — restores the body's own NAD+ pool to support cellular energy metabolism, mitochondrial function, and physical performance. Core "restore-not-replace" hero ingredient.

Adaptogen supporting healthy energy, stress resilience, and healthy sexual function.

Membrane phospholipid that supports cognition and helps blunt the stress-driven cortisol response — bridges the PM stress-down-regulation and recovery goals of RENEW.

Procyanidin/flavonoid-rich French maritime pine bark extract; antioxidant and endothelial support — increases eNOS activity / nitric-oxide availability and reduces oxidative stress and platelet aggregation.

Flavonoid antioxidant / anti-inflammatory; classic senolytic co-factor (pairs with fisetin/dasatinib in research); supports vascular tone and a healthy inflammatory response.

Foundational TCM kidney-Yin tonic; source of catalpol and iridoid glycosides studied (preclinically) for anti-inflammatory, anti-oxidant, bone-metabolism, and renal-protective activity. A "restorative/renew" base herb in the RENEW stack.

Adaptogenic medicinal mushroom supporting immune balance, recovery, and a calm sense of well-being in the PM stack.

Polyphenol sirtuin-pathway activator and antioxidant; supports the body's own metabolic and vascular signaling. Often paired conceptually with NAD+ precursors (sirtuins are NAD+-dependent).

Adaptogen; supports stress resilience, reduces stress-related fatigue, and supports mental performance under fatigue. On-brand: modulates the body's own stress response rather than stimulating.

Adaptogenic berry supporting stress resilience, antioxidant defense, and recovery; rounds out the RENEW adaptogen profile.

Ayurvedic women's reproductive/hormonal tonic; supports hormonal balance, stress resilience, and well-being across the menopausal transition.

Polyamine that induces autophagy ("cellular self-cleaning"); supports cognitive and cardiovascular healthy aging. Complements the renew/cellular-renewal narrative.

**Natural, zero-calorie sweetener / palatability agent** — masks bitterness of herbal actives and improves sachet taste without sugar or glycemic load. Functional excipient, not a health actor.

Conditionally essential amino acid; supports cardiovascular function, cellular osmoregulation, mitochondrial function, and is a candidate longevity nutrient (circulating taurine declines with age).

Methyl donor — supplies methyl groups to offset the methylation demand created by NAD+ precursor metabolism (NMN/niacinamide), and supports healthy homocysteine metabolism. Methylation-support partner to NMN.

Restore the body's own testosterone output endogenously and blunt cortisol — the brand's flagship "restore, not replace" androgen support, paired with energy, libido, and stress-resilience benefits.

Pyrimidine nucleotide; substrate for membrane phospholipid (CDP-choline pathway) synthesis. Pairs with CDP-choline and DHA to support synaptic membrane formation.

Essential precursor of Coenzyme A (CoA) and acyl-carrier protein — central to fatty-acid synthesis/oxidation, the TCA cycle, and adrenal/steroid and energy metabolism. Supports the body's own energy-production machinery.

Cofactor (as pyridoxal-5'-phosphate, P5P) for >100 enzymes — amino-acid metabolism, neurotransmitter synthesis (serotonin, GABA, dopamine), and homocysteine clearance. Supports the body's own neurotransmitter and methylation machinery.

Water-soluble antioxidant and essential cofactor for collagen synthesis, immune function, and catecholamine metabolism; regenerates other antioxidants and supports endothelial nitric-oxide bioavailability.

Foundational fat-soluble prohormone supporting calcium homeostasis, bone integrity, normal immune function, and muscle function — restores a commonly low endogenous status rather than overriding it.

Primary lipid-phase (fat-soluble) antioxidant; protects cell membranes and LDL particles from lipid peroxidation. Mixed tocopherols (incl. gamma) chosen deliberately over high-dose alpha alone.

Activates vitamin-K-dependent proteins (osteocalcin, matrix Gla protein) that direct calcium INTO bone and AWAY from arteries — the rational partner to D3. Supports the body's own calcium-routing machinery.

Essential cofactor for the body's own testosterone synthesis (Leydig-cell steroidogenesis) plus immune and antioxidant support — a true "restore, not replace" nutrient: it permits endogenous hormone production rather than supplying any hormone.